Pre-Clinical Studies

CDMO

Pre-Clinical Studies

Clinical Studies

Radiopharmaceuticals R&D Service

Imaging Service

Pre-Clinical Studies

Pharmacokinetics/Bio-distribution

At the preclinical stage, MITRO provides sponsors with new drug R&D services such as PK and PD studies, safety evaluation, etc. using tracers and in vivo molecular imaging technology, covering various types of drugs such as small molecules, peptides, antibodies, cells, polysaccharides, nucleic acids, etc. With extensive experience in molecular labelling, the business covers the translational research including mice, rats, rabbits, dogs, pigs and NHPs. 

 

 1  3H/14C/125I Ex Vivo ADME Studies 

MITRO can conduct quantitative ex vivo ADME study services by radiolabeling with 3H/14C/125I and testing by liquid scintillator or GAMMA counter. 

 

Biodistribution 

1

 

Faeces and excretion 

1

 

 

Bile excretion 

1

 

 

1

 

Liquid Scintillator 

 

1

 

Gamma Counter 

 

 

 

1  89Zr Labeled CAR-T cells: Targeting and Functioning in Solid Tumor

                 （Note：The White arrow in the figure points to the tumor site）

 

1Bio-distribution of 89Zr Labeled mAb in Cynomolgus Macaques by Intravenous Infusion 

 

 1 MITRO can perform radioisotope labeling for neurological drugs to study drug penetration through the blood-brain barrier.